Enteral Feeding as an Adjunct to Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy (HIE)

Whole body hypothermia is routinely used to reduce neonatal brain injury in infants with HIE. Enteral feeding is withheld during hypothermia a majority of the time without evidence to support this practice. This study aims to evaluate the effects of enteral feeding as an adjunct to hypothermia for HIE by looking at serum inflammatory mediators to see if there is a greater degree of systemic inflammation in neonates who were not fed compared with neonates who were fed in serum samples currently in our biorepository.The long-term objective of the proposed project is to establish the safety and efficacy of enteral feeding during hypothermia in neonates with HIE.

 

Investigator(s): Dr. Michael Weiss, Dr. Josef Neu, Dr. Lilly Chang, Dr. Marisa Pacella

Intervention(s):

  • Database Entry
  • Process of already collected samples from a Biorepository of FN3

 

Eligibility Criteria:


Study Population: Infants previously enrolled in hypothermia study

Sexes Eligible: All

 

Inclusion Criteria:


  • Gestational Age greater than or equal to 35 weeks gestation
  • Birth weight greater than or equal to 1.8 kg
  • Less than or equal to 6 hours since insult occurred
  • Severe hypoxic-ischemic encepholopathy (HIE)